This is the Web Implementation of the tools detailed in a manuscript by Colantuoni et al. (Bioinformatics, 2002 Nov;18(11):1540-1). "SNOMAD (Standardization and NOrmalization of MicroArray Data): Web-accessible Gene Expression Data Analysis"
SNOMAD is a program for the standardization and normalization of gene expression datasets. In addition to conventional transformations and visualization tools, SNOMAD includes two non-linear transformations which correct for bias and variance which are non-uniformly distributed across the range of microarray element signal intensities: local mean normalization and local variance correction (Z-score generation using a locally calculated standard deviation).
It is written as a perl script using the R language and environment and can be run over the internet from the Pevsner Lab Server. Alternatively you can download the program and run it locally under the UNIX operating system (requires the R Project Software).