- 3rd Edition home
- Resources for Teachers
- The book's webpage at Wiley
- Part I : Bioinformatics : Analyzing DNA, RNA, and Protein Sequences
- Part II: Functional Genomics: Bioinformatics from DNA to RNA to Protein
- Chapter 8: The Eukaryotic Chromosome
- Chapter 9: DNA Analysis: Microarrays and Next Generation Sequencing
- Chapter 10: Bioinformatic Approaches to RNA
- Chapter 11: RNA Analysis: Microarrays and Next Generation Sequencing
- Chapter 12: Proteomics
- Chapter 13: Protein Structure
- Chapter 14: Functional Genomics
- Part III: Genomics
- Second edition
Bioinformatics and Functional Genomics 3rd Edition
Part I: Bioinformatics: Analyzing DNA, RNA and Protein Sequences
This part of the book deals with some of the fundamental operations in bioinformatics. We learn how to access different kinds of molecular data (such as protein and DNA sequences) in Chapter 2. We perform pairwise alignment in Chapter 3, and then search a query (such as a protein or DNA sequence) against an entire database using BLAST in Chapter 4. In Chapter 5 we examine advanced techniques for searching databases, such as the sensitive DELTA-BLAST algorithm for searching protein databases using position-specific scoring matrices, and specialized methods for searching genomic DNA databases. We extend the alignment problem to multiple sequences in Chapter 6, and we visualize multiple sequence alignments using the tools of phylogeny in Chapter 7. That chapter also introduces principles of molecular evolution.