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Lysosomes are acidic organelles that are a major site of catabolism in the cell. Lysosomes contain acidic hydrolases, as well as other enzymes and proteins. Several dozen diseases are known to occur in which the gene encoding a lysosomal enzyme is defective. Other diseases occur when substances to be degraded fail to reach the lysosome. Our laboratory studies some of the proteins that function in transporting macromolecules to the lysosome.

Image gallery

Electron micrograph of human skin cell fibroblasts from a patient with an undiagnosed lysosomal disorder.

Visualization of lysosomes in normal human skin fibroblasts using Lysotracker dye (Molecular Probes, Inc.)

Electron micrograph of human skin cell fibroblasts from a patient with an undiagnosed lysosomal disorder.

Electron micrograph of human skin cell fibroblasts from a patient with an undiagnosed lysosomal disorder.

Electron micrograph of human skin cell fibroblasts from a patient with an undiagnosed lysosomal disorder.

Electron micrograph of human skin cell fibroblasts from a patient with an undiagnosed lysosomal disorder.