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| Introduction | Introduction to lead poisoning Human exposure to lead (Pb2+), especially at a young age, impairs a range of neurological functions. A blood Pb2+ level above 10 ug/dL (~ 0.5 uM) is considered potentially hazardous. Recently it has been reported that approximately 5% of children in the U.S. have blood Pb2+ levels greater than or equal to 10 ug/dL. Thus Pb2+ poisoning is one of the most critical environmental health hazards affecting children today. The symptoms of lead poisoning vary with dose, and include cognitive decline, hyperactivity, and anemia. The mechanism of Pb2+ toxicity remains poorly understood. One possible mechanism of its effects may be its influence on synaptic activity. We are studying the molecular basis of lead neurotoxicity in the brain, as described in the approach section. .
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| Approach | |
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