Welcome


We have analyzed SNP data to define relatedness between individuals, including K0, K1, and K2 which are estimates of the Cotterman coefficients of relatedness k0, k1, and k2. This web page provides access to an executable to run kcoeff, a program that accepts SNP genotype data as input and calculates K0, K1, and K2.


We recommend using SNPduo++ to measure the IBS2*_ratio (IBS2*/[IBS2* + IBS0]):

We plot our results using Partek software.

README file including details of how to run the kcoeff program.

Sample file for use with our IBD estimation software (20 MB tab-delimited text file).

Pedigree structure of the sample file (powerpoint).

Download kcoeff compiled for linux (CentOS 5.7). Contains both i386 (32 bit) and x84_64 (64 bit) binaries.

Download kcoeff compiled for Mac OSX 10.7.

Download kcoeff compiled for solaris 11. Contains both i386 (32 bit) and x84_64 (64 bit) binaries.

Please direct any questions to Eric Stevens (esteven9@jhmi.edu) or Jonathan Pevsner (pevsner@kennedykrieger.org). Platform-specific compilation and documentation provided by Matt Shirley.


Reference:Stevens EL, Heckenberg G, Roberson EDO, Baugher JD, Downey TJ, et al. (2011) Inference of Relationships in Population Data Using Identity-by-Descent and Identity-by-State. PLoS Genet 7(9): e1002287. doi:10.1371/journal.pgen.1002287

This page updated January 23, 2012.

Link back to Pevsner Webpage.