Additional Table 3: Results of Wilcoxon rank test for analysis of functional group regulation.        

 

Abbreviation: fg, functional group; GO, Gene Ontology; U, underexpressed; O, overexpressed  

Explanation of headers: rank refers to the place among the approximately 10,000 probesets analyzed (9,583 in astrocytes; 10,497 in cerebellum; 9,704 in cerebrum; 10,624 in heart).

For example, a rank of 19 means there were 18 gene expression measurements smaller than the one observed 

Direction refers to direction on regulation (underexpressed, U; overexpressed, O)

 

astrocyte

 

 

Source

# genes per fg

GO group

p value

rank

direction

 

1

astrocyte

1

GO:0030295

0.004

19

U

 

2

astrocyte

1

GO:0015232

0.0083

40

U

 

3

astrocyte

1

GO:0007321

0.0163

78

U

 

4

astrocyte

1

GO:0017128

0.0213

102

O

 

5

astrocyte

1

GO:0005189

0.0223

107

O

 

6

astrocyte

1

GO:0048154

0.024

115

O

 

7

astrocyte

1

GO:0048155

0.024

115

O

 

8

astrocyte

1

GO:0048156

0.024

115

O

 

9

astrocyte

1

GO:0001515

0.0248

119

U

 

10

astrocyte

1

GO:0007499

0.0261

125

O

 

11

astrocyte

1

GO:0007638

0.0311

149

U

 

12

astrocyte

1

GO:0001772

0.0313

150

U

 

13

astrocyte

1

GO:0042608

0.0313

150

U

 

14

astrocyte

1

GO:0019208

0.0342

164

O

 

15

astrocyte

1

GO:0046332

0.0342

164

O

 

16

astrocyte

1

GO:0004978

0.0376

180

U

 

17

astrocyte

1

GO:0008281

0.0392

188

U

 

18

astrocyte

1

GO:0016923

0.0493

236

O

 

19

astrocyte

1

GO:0008395

0.0526

252

U

 

20

astrocyte

1

GO:0015485

0.0532

255

U

 

 

 

 

Source

# genes per fg

GO group

p value

rank1

rank2

direction

1

astrocyte

2

GO:0008147

0.0001

37

51

O

2

astrocyte

2

GO:0007589

0.0004

32

170

U

3

astrocyte

2

GO:0008048

0.0004

32

170

U

4

astrocyte

2

GO:0017147

0.0073

34

788

O

5

astrocyte

2

GO:0030935

0.0084

234

644

O

6

astrocyte

2

GO:0004666

0.0142

377

766

U

7

astrocyte

2

GO:0007494

0.0156

227

972

U

8

astrocyte

2

GO:0030377

0.0188

159

1155

O

9

astrocyte

2

GO:0005698

0.0191

600

724

U

10

astrocyte

2

GO:0030695

0.0203

619

746

O

11

astrocyte

2

GO:0050664

0.0424

167

1806

U

12

astrocyte

2

GO:0015035

0.0516

614

1564

O

13

astrocyte

2

GO:0045595

0.0633

951

1460

U

14

astrocyte

2

GO:0005811

0.0767

107

2547

O

15

astrocyte

2

GO:0007595

0.0818

173

2569

O

16

astrocyte

2

GO:0005154

0.0883

1412

1437

O

17

astrocyte

2

GO:0009320

0.103

1173

1903

U

18

astrocyte

2

GO:0016899

0.1147

1454

1792

U

19

astrocyte

2

GO:0005971

0.1307

1365

2100

U

20

astrocyte

2

GO:0004325

0.1375

1665

1889

O

 

 

 

Source

# genes per fg

GO group

-log10 p value

rank1

rank2

 

1

Astrocyte

141

GO:0004930

8.82

3395

4813

 

2

Astrocyte

15

GO:0005581

8.45

9006

4785

 

3

Astrocyte

49

GO:0005201

7.85

7028

4781

 

4

Astrocyte

14

GO:0005583

7.59

8907

4786

 

5

Astrocyte

307

GO:0005783

6.44

5582

4766

 

6

Astrocyte

734

GO:0005887

6.02

4311

4832

 

7

Astrocyte

381

GO:0006952

5.16

4168

4818

 

8

Astrocyte

120

GO:0005578

5.14

5918

4778

 

9

Astrocyte

66

GO:0007276

4.72

3342

4802

 

10

Astrocyte

73

GO:0005216

4.67

3421

4803

 

11

Astrocyte

482

GO:0007166

4.51

4280

4819

 

12

Astrocyte

122

GO:0043232

4.14

3804

4805

 

13

Astrocyte

23

GO:0005604

4.06

7052

4787

 

14

Astrocyte

82

GO:0007517

3.7

5923

4782

 

15

Astrocyte

16

GO:0008643

3.66

7345

4788

 

16

Astrocyte

229

GO:0006811

3.6

4130

4808

 

17

Astrocyte

8

GO:0019956

3.56

1237

4795

 

18

Astrocyte

5

GO:0001527

3.46

9218

4790

 

19

Astrocyte

10

GO:0016917

3.43

1678

4795

 

20

Astrocyte

111

GO:0019226

3.43

3863

4803

 

 

 

 

Source

# genes per fg

GO group

-log10 p value

mean1

mean2

 

1

astrocyte

15

GO:0005581

6.11

0.33

-0.01

 

2

astrocyte

307

GO:0005783

6.05

0.03

-0.02

 

3

astrocyte

14

GO:0005583

5.3

0.29

-0.01

 

4

astrocyte

122

GO:0043232

5.1

-0.06

-0.01

 

5

astrocyte

141

GO:0004930

4.9

-0.09

-0.01

 

6

astrocyte

66

GO:0007276

4.61

-0.08

-0.01

 

7

astrocyte

734

GO:0005887

4.59

-0.04

-0.01

 

8

astrocyte

11

GO:0016862

3.66

0.04

-0.01

 

9

astrocyte

16

GO:0008643

3.62

0.1

-0.01

 

10

astrocyte

309

GO:0006259

3.4

-0.04

-0.01

 

11

astrocyte

120

GO:0005578

3.17

0.09

-0.02

 

12

astrocyte

82

GO:0007517

3.17

0.06

-0.01

 

13

astrocyte

381

GO:0006952

3.07

-0.04

-0.01

 

14

astrocyte

227

GO:0007155

3.05

0.04

-0.01

 

15

astrocyte

12

GO:0045012

3.04

-0.12

-0.01

 

16

astrocyte

8

GO:0019956

2.94

-0.21

-0.01

 

17

astrocyte

49

GO:0005201

2.94

0.19

-0.01

 

18

astrocyte

10

GO:0016917

2.9

-0.17

-0.01

 

19

astrocyte

7

GO:0005815

2.86

-0.13

-0.01

 

20

astrocyte

6

GO:0008538

2.85

-0.11

-0.01

 

 

 

 

cerebellum

 

 

Source

# genes per fg

GO group

p value

rank

direction

 

1

cerebellum

1

GO:0016019

0.0051

27

U

 

2

cerebellum

1

GO:0016910

0.0076

40

O

 

3

cerebellum

1

GO:0045445

0.0076

40

O

 

4

cerebellum

1

GO:0009591

0.0084

44

O

 

5

cerebellum

1

GO:0030936

0.0269

141

U

 

6

cerebellum

1

GO:0005012

0.0299

157

O

 

7

cerebellum

1

GO:00049781

0.0326

171

U

 

8

cerebellum

1

GO:00152321

0.0343

180

U

 

9

cerebellum

1

GO:0005972

0.0488

256

O

 

10

cerebellum

1

GO:0008001

0.0488

256

O

 

11

cerebellum

1

GO:0005335

0.0549

288

O

 

12

cerebellum

1

GO:0015222

0.0549

288

O

 

13

cerebellum

1

GO:0030567

0.0549

288

U

 

14

cerebellum

1

GO:0017015

0.0614

322

U

 

15

cerebellum

1

GO:0008514

0.0646

339

U

 

16

cerebellum

1

GO:00481541

0.0655

344

O

 

17

cerebellum

1

GO:00481551

0.0655

344

O

 

18

cerebellum

1

GO:00481561

0.0655

344

O

 

19

cerebellum

1

GO:0005582

0.0716

376

U

 

20

cerebellum

1

GO:0008046

0.0726

381

U

 

 

 

 

Source

# genes per fg

GO group

p value

rank1

rank2

direction

1

cerebellum

2

GO:0008367

0.0004

27

176

O

2

cerebellum

2

GO:0005066

0.0029

214

355

U

3

cerebellum

2

GO:0005618

0.0062

320

507

O

4

cerebellum

2

GO:0005173

0.0229

48

1542

U

5

cerebellum

2

GO:0007515

0.0265

425

1284

O

6

cerebellum

2

GO:0008389

0.0453

896

1340

O

7

cerebellum

2

GO:0005930

0.0487

1036

1282

O

8

cerebellum

2

GO:0004126

0.0505

129

2231

O

9

cerebellum

2

GO:0046875

0.052

967

1427

U

10

cerebellum

2

GO:0004161

0.0526

695

1713

O

11

cerebellum

2

GO:0016363

0.0529

822

1593

U

12

cerebellum

2

GO:0005903

0.0546

1087

1366

O

13

cerebellum

2

GO:00075951

0.0628

1079

1553

O

14

cerebellum

2

GO:0015216

0.0701

557

2223

O

15

cerebellum

2

GO:0008393

0.0837

514

2524

O

16

cerebellum

2

GO:0016810

0.0864

631

2455

O

17

cerebellum

2

GO:0009053

0.0928

1402

1796

O

18

cerebellum

2

GO:0001772

0.0959

1288

1963

O

19

cerebellum

2

GO:0005929

0.0996

610

2703

O

20

cerebellum

2

GO:0007632

0.1144

1074

2477

O

 

 

 

Source

# genes per fg

GO group

-log10 p value

rank1

rank2

 

1

cerebellum

933

GO:0005887

1.43E+01

5991

5177

 

2

cerebellum

469

GO:0003723

1.26E+01

4248

5296

 

3

cerebellum

170

GO:0019226

1.01E+01

6746

5224

 

4

cerebellum

212

GO:0004930

9.90E+00

6574

5222

 

5

cerebellum

430

GO:0006952

9.76E+00

6162

5210

 

6

cerebellum

2194

GO:0005634

9.10E+00

4895

5342

 

7

cerebellum

592

GO:0007166

7.57E+00

5922

5209

 

8

cerebellum

212

GO:0003735

7.09E+00

4144

5272

 

9

cerebellum

1126

GO:0003677

6.90E+00

4798

5303

 

10

cerebellum

286

GO:0016070

6.41E+00

4352

5274

 

11

cerebellum

337

GO:0007399

5.89E+00

6035

5223

 

12

cerebellum

495

GO:0003676

5.84E+00

4608

5281

 

13

cerebellum

147

GO:0005840

5.79E+00

4059

5266

 

14

cerebellum

120

GO:0005216

5.67E+00

6553

5234

 

15

cerebellum

1596

GO:0006139

5.53E+00

4922

5308

 

16

cerebellum

84

GO:0000785

4.76E+00

3835

5260

 

17

cerebellum

324

GO:0006996

4.32E+00

4575

5270

 

18

cerebellum

13

GO:0005583

4.23E+00

1875

5253

 

19

cerebellum

15

GO:0016917

4.17E+00

8364

5245

 

20

cerebellum

886

GO:0044260

4.02E+00

4869

5284

 

 

 

 

Source

# genes per fg

GO group

-log10 p value

mean1

mean2

 

1

cerebellum

933

GO:0005887

1.09E+01

0.03

0

 

2

cerebellum

469

GO:0003723

1.02E+01

-0.02

0.01

 

3

cerebellum

212

GO:0003735

7.95E+00

-0.03

0.01

 

4

cerebellum

212

GO:0004930

7.89E+00

0.06

0

 

5

cerebellum

170

GO:0019226

7.48E+00

0.06

0

 

6

cerebellum

2194

GO:0005634

7.45E+00

-0.01

0.01

 

7

cerebellum

592

GO:0007166

6.65E+00

0.03

0

 

8

cerebellum

147

GO:0005840

6.33E+00

-0.03

0.01

 

9

cerebellum

430

GO:0006952

5.97E+00

0.04

0

 

10

cerebellum

1596

GO:0006139

5.27E+00

-0.01

0.01

 

11

cerebellum

337

GO:0007399

5.02E+00

0.04

0

 

12

cerebellum

13

GO:0008304

4.60E+00

-0.05

0.01

 

13

cerebellum

286

GO:0016070

4.34E+00

-0.02

0.01

 

14

cerebellum

15

GO:0016917

4.19E+00

0.1

0.01

 

15

cerebellum

1126

GO:0003677

4.14E+00

-0.01

0.01

 

16

cerebellum

84

GO:0000785

4.09E+00

-0.04

0.01

 

17

cerebellum

495

GO:0003676

3.97E+00

-0.01

0.01

 

18

cerebellum

12

GO:0000228

3.71E+00

-0.06

0.01

 

19

cerebellum

323

GO:0005783

3.63E+00

-0.02

0.01

 

20

cerebellum

126

GO:0043232

3.54E+00

-0.03

0.01

 

 

 

cerebrum

 

 

Source

# genes per fg

GO group

p value

rank

direction

 

1

cerebrum

1

GO:0005930

0.0078

38

U

 

2

cerebrum

1

GO:0005330

0.0124

60

O

 

3

cerebrum

1

GO:00051891

0.0183

89

O

 

4

cerebrum

1

GO:0004657

0.021

102

O

 

5

cerebrum

1

GO:0005157

0.0221

107

U

 

6

cerebrum

1

GO:0004055

0.0239

116

O

 

7

cerebrum

1

GO:0005555

0.0254

123

U

 

8

cerebrum

1

GO:0005577

0.0272

132

U

 

9

cerebrum

1

GO:0008048

0.0289

140

U

 

10

cerebrum

1

GO:00049782

0.0311

151

O

 

11

cerebrum

1

GO:0008437

0.0342

166

O

 

12

cerebrum

1

GO:00053351

0.0385

187

U

 

13

cerebrum

1

GO:00152221

0.0385

187

U

 

14

cerebrum

1

GO:0005142

0.0592

287

U

 

15

cerebrum

1

GO:0030219

0.0592

287

U

 

16

cerebrum

1

GO:0004203

0.0608

295

U

 

17

cerebrum

1

GO:00154851

0.067

325

U

 

18

cerebrum

1

GO:0017127

0.067

325

U

 

19

cerebrum

1

GO:0030288

0.0678

329

O

 

20

cerebrum

1

GO:0008225

0.0686

333

U

 

 

 

 

Source

# genes per fg

GO group

p value

rank1

rank2

direction

1

cerebrum

2

GO:0015067

0.0006

80

157

O

2

cerebrum

2

GO:00056181

0.0047

297

369

O

3

cerebrum

2

GO:0001515

0.005

182

505

O

4

cerebrum

2

GO:00455951

0.0122

47

1024

O

5

cerebrum

2

GO:0006854

0.0165

474

775

U

6

cerebrum

2

GO:00093201

0.0252

529

1012

O

7

cerebrum

2

GO:0003762

0.026

291

1275

U

8

cerebrum

2

GO:0001850

0.0277

370

1246

U

9

cerebrum

2

GO:0004875

0.0277

370

1246

U

10

cerebrum

2

GO:0008509

0.0316

450

1277

U

11

cerebrum

2

GO:0040014

0.0501

786

1387

U

12

cerebrum

2

GO:00506641

0.0508

23

2165

U

13

cerebrum

2

GO:0007444

0.055

146

2130

U

14

cerebrum

2

GO:00056981

0.0618

471

1943

U

15

cerebrum

2

GO:0004096

0.0639

827

1627

O

16

cerebrum

2

GO:0017151

0.0803

346

2404

U

17

cerebrum

2

GO:0051180

0.1351

1129

2438

U

18

cerebrum

2

GO:0017069

0.1362

858

2724

U

19

cerebrum

2

GO:0005517

0.1386

1735

1879

U

20

cerebrum

2

GO:00059711

0.1394

1577

2047

O

 

 

 

Source

# genes per fg

GO group

-log10 p value

rank1

rank2

 

1

cerebrum

417

GO:0005739

 Inf

6013

4800

 

2

cerebrum

86

GO:0015077

9.12

6703

4836

 

3

cerebrum

1495

GO:0006139

8.97

4446

4927

 

4

cerebrum

299

GO:0016491

8.32

5786

4823

 

5

cerebrum

2072

GO:0005634

6.93

4563

4931

 

6

cerebrum

558

GO:0003700

5.75

4302

4886

 

7

cerebrum

485

GO:0003676

5.66

4265

4883

 

8

cerebrum

31

GO:0003954

5.2

7121

4845

 

9

cerebrum

49

GO:0005102

4.88

6592

4844

 

10

cerebrum

1071

GO:0003677

4.68

4509

4895

 

11

cerebrum

166

GO:0004930

4.54

3951

4868

 

12

cerebrum

25

GO:0004129

3.74

6946

4847

 

13

cerebrum

167

GO:0005576

3.62

4063

4866

 

14

cerebrum

147

GO:0009308

3.27

5646

4840

 

15

cerebrum

15

GO:0030106

3.16

7304

4849

 

16

cerebrum

466

GO:0003723

3.06

4431

4874

 

17

cerebrum

4

GO:0004667

3.02

227

4854

 

18

cerebrum

304

GO:0006091

3.01

5374

4836

 

19

cerebrum

73

GO:0008083

3

3778

4861

 

20

cerebrum

35

GO:0046872

2.93

6387

4847

 

 

 

 

Source

# genes per fg

GO group

-log10 p value

mean1

mean2

 

1

cerebrum

417

GO:0005739

13.85

0.03

0

 

2

cerebrum

86

GO:0015077

8.43

0.05

0

 

3

cerebrum

1495

GO:0006139

6.7

-0.02

0

 

4

cerebrum

2072

GO:0005634

6.26

-0.01

0

 

5

cerebrum

485

GO:0003676

5.91

-0.02

0

 

6

cerebrum

299

GO:0016491

5.48

0.02

0

 

7

cerebrum

31

GO:0003954

5.42

0.06

0

 

8

cerebrum

1071

GO:0003677

4.87

-0.02

0

 

9

cerebrum

25

GO:0004129

4.07

0.05

0

 

10

cerebrum

466

GO:0003723

3.83

-0.02

0

 

11

cerebrum

558

GO:0003700

3.62

-0.02

0

 

12

cerebrum

147

GO:0009308

3.46

0.03

0

 

13

cerebrum

273

GO:0016070

3.11

-0.02

0

 

14

cerebrum

8

GO:0000263

3.07

0.04

0

 

15

cerebrum

27

GO:0004386

2.94

-0.05

0

 

16

cerebrum

108

GO:0005635

2.88

-0.03

0

 

17

cerebrum

4

GO:0008312

2.88

0.02

0

 

18

cerebrum

3

GO:0008025

2.78

0.27

0

 

19

cerebrum

49

GO:0005102

2.75

0.07

0

 

20

cerebrum

15

GO:0006805

2.63

-0.08

0

 

 

 

heart

 

 

Source

# genes per fg

GO group

p value

rank

direction

 

1

heart

1

GO:0007320

0.0006

3

U

 

2

heart

1

GO:0006906

0.0021

11

U

 

3

heart

1

GO:0030181

0.004

21

O

 

4

heart

1

GO:0005130

0.0041

22

U

 

5

heart

1

GO:0030165

0.0128

68

U

 

6

heart

1

GO:0008301

0.0194

103

U

 

7

heart

1

GO:00154852

0.0239

127

O

 

8

heart

1

GO:00171271

0.0239

127

O

 

9

heart

1

GO:0009434

0.025

133

O

 

10

heart

1

GO:0030317

0.025

133

O

 

11

heart

1

GO:0007401

0.028

149

U

 

12

heart

1

GO:0001533

0.0294

156

U

 

13

heart

1

GO:0030216

0.0294

156

U

 

14

heart

1

GO:00082251

0.0352

187

O

 

15

heart

1

GO:0015643

0.0352

187

O

 

16

heart

1

GO:0042056

0.0352

187

O

 

17

heart

1

GO:0009315

0.0369

196

U

 

18

heart

1

GO:0004362

0.0375

199

O

 

19

heart

1

GO:0001666

0.0384

204

O

 

20

heart

1

GO:0005061

0.0384

204

O

 

 

 

 

Source

# genes per fg

GO group

p value

rank1

rank2

direction

1

heart

2

GO:0015250

0.0025

89

445

U

2

heart

2

GO:0030492

0.0105

391

700

U

3

heart

2

GO:00056182

0.0138

289

960

O

4

heart

2

GO:0004203

0.0159

127

1214

U

5

heart

2

GO:00050661

0.0263

342

1383

U

6

heart

2

GO:0016623

0.0265

71

1659

U

7

heart

2

GO:0030345

0.0297

319

1513

U

8

heart

2

GO:0008142

0.0299

221

1618

O

9

heart

2

GO:0008431

0.033

929

1003

U

10

heart

2

GO:0004478

0.0398

876

1245

O

11

heart

2

GO:0015232

0.0474

222

2091

O

12

heart

2

GO:0030553

0.0573

55

2490

U

13

heart

2

GO:00163631

0.067

1163

1588

O

14

heart

2

GO:0009607

0.0703

931

1886

U

15

heart

2

GO:00075151

0.0776

1210

1751

U

16

heart

2

GO:00083931

0.0842

225

2858

U

17

heart

2

GO:0008434

0.0859

406

2708

U

18

heart

2

GO:00506642

0.087

665

2470

O

19

heart

2

GO:0007635

0.0873

1143

1996

U

20

heart

2

GO:0016343

0.0908

1035

2168

U

 

 

 

Source

# genes per fg

GO group

-log10 p value

rank1

rank2

 

1

heart

446

GO:0005739

  Inf

6530

5259

 

2

heart

485

GO:0006952

11.54

4363

5358

 

3

heart

86

GO:0015077

8.22

7228

5297

 

4

heart

201

GO:0007267

7.24

4150

5335

 

5

heart

948

GO:0005887

6.48

4827

5360

 

6

heart

594

GO:0007166

5.87

4721

5348

 

7

heart

215

GO:0005576

5.09

4388

5332

 

8

heart

812

GO:0007165

4.43

4886

5348

 

9

heart

215

GO:0004930

4.38

4464

5330

 

10

heart

7

GO:0015101

3.87

891

5315

 

11

heart

31

GO:0003954

3.75

7374

5306

 

12

heart

380

GO:0046914

3.74

4734

5334

 

13

heart

28

GO:0006937

3.64

7447

5307

 

14

heart

428

GO:0046907

3.53

5838

5290

 

15

heart

20

GO:0007507

3.5

7781

5308

 

16

heart

74

GO:0005743

3.29

6547

5304

 

17

heart

322

GO:0006259

3.24

5892

5294

 

18

heart

8

GO:0007623

3.16

1634

5315

 

19

heart

26

GO:0004129

2.99

7286

5308

 

20

heart

45

GO:0003697

2.9

6782

5306

 

 

 

 

Source

# genes per fg

GO group

-log10 p value

mean1

mean2

 

1

heart

446

GO:0005739

15.18

0.04

-0.01

 

2

heart

86

GO:0015077

9.37

0.07

-0.01

 

3

heart

485

GO:0006952

7.64

-0.06

-0.01

 

4

heart

31

GO:0003954

5.28

0.07

-0.01

 

5

heart

428

GO:0046907

4.63

0.02

-0.01

 

6

heart

201

GO:0007267

3.99

-0.07

-0.01

 

7

heart

74

GO:0005743

3.78

0.04

-0.01

 

8

heart

594

GO:0007166

3.76

-0.04

-0.01

 

9

heart

948

GO:0005887

3.71

-0.03

-0.01

 

10

heart

215

GO:0005576

3.62

-0.06

-0.01

 

11

heart

14

GO:0006944

3.33

0.06

-0.01

 

12

heart

322

GO:0006259

3.09

0.02

-0.01

 

13

heart

28

GO:0006937

3.03

0.08

-0.01

 

14